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Interactions between mature dendritic cell and naive CD4+ T cells leads to the polarization of naive CD4+ T cells into Th1, Th2, and Th17 cells in presence cytokines IL-12, IL-4, and IL-6, respectively ( IL-4 signaling: Antigen-presenting dendritic cells activate the naive CD4+ T-cells to differentiate into Th2 cells in the IL-4 cytokine-enriched airway microenvironment, promoting airway eosinophilic inflammation and consequent bronchial hyperresponsiveness ( Figure 6 ( Supplementary Data of the Supplementary Materials

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