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👀 Did you know reflux can actually change the cells in your esophagus if you ignore it?, ‌, • Most people think reflux = heartburn. But with silent reflux, you don’t always feel that burn. Instead, ...

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Urolithin A activates the PTEN induced kinase 1 (PINK1)/Parkin RBR E3 ubiquitin protein ligase (PRKN) pathway, which tags dysfunctional mitochondria for degradation, while also stimulating mitochondrial biogenesis via the sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) signalling axis (Reference Ryu, Mouchiroud and Andreux15)