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[5] Use of Lipo-C Injection is contraindicated in patients with known hypersensitivity to methionine, choline salts, carnitine, dexpanthenol, or any formulation excipients, as well as in individuals with severe hepatic failure in whom augmented methionine intake could precipitate hypermethioninemia and encephalopathy

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[1] When combined, the cumulative effect on heart rate and blood pressure may be clinically significant, particularly in patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias