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Furthermore, certain targeted cancer therapies (including anaplastic lymphoma kinase inhibitors, cyclin-dependent kinase 4 (CDK4) and CDK6 inhibitors, mesenchymal-epithelial transition tyrosine kinase inhibitors (TKIs), and polyadenosine diphosphate ribose polymerase inhibitors) have been associated with impairment of the tubular secretion of creatinine, resulting in underestimation of GFR using SCr-based regression equations (that is, a ‘pseudo-AKI’ effect)
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