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These aggressors cause what’s known as “cellular destabilization,” which leads to signs of aging, like sagging skin, fine lines, rough texture, and hyperpigmentation

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96 In addition, repeated lung injury inhibits the expression of chemokine receptor CXCR7 on lung capillary endothelial cells (PCECs) and recruits VEGFR1 + perivascular macrophages, causing excessive activation of the Wnt/β-catenin pathway in PCECs