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By introducing neurotoxins such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), paraquat, and rotenone, toxin-based models suffer from overloaded oxidative stress which provokes the speedy degeneration of mDA that mimic the sporadic PD 17,18
Use sunscreen during and after treatment to prevent further skin discoloration.
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