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Mice sensitized by intraperitoneal injection of ovalbumin and intranasally infused with CuO NPs exacerbated the development of asthma by increasing AHR, inflammatory cell count in bronchoalveolar lavage (BAL) fluid, mucus secretion, serum immunoglobulin E (IgE) levels, allergic inflammatory markers, including IL-5 and IL-13, and ROS production in BAL fluid (Park et al., 2016)