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All three peptides show promising results in preclinical and early clinical studies, but further research is needed to confirm their long-term safety and efficacy

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Many studies show that serotonin has a potential stimulatory effect, especially in the later stage of the cancer process, including cell proliferation and migration, metastatic dissemination, and tumor angiogenesis [168,169], while emerging findings suggest that serotonin may play a dual role in CRC, where the impairment of the serotonin synthesis is linked with inflammatory reactions that may promote the initiation in colorectal tumorigenesis (Figure 3) [77]