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LCMS (ES, m/z) calculated for C 30 H 35 N 6 O 3 + [(M + H) + ] 527.3, observed 527.2 Synthesis of tert -Butyl (R)-3-(4-(1-cyclopropyl-[1,2,4] triazolo[4,3-a]quinolin-7-yl)piperazine-1-carbonyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (8t) Intermediate 6c was treated with commercial compound 7f

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This separation means synergistic benefits without receptor competition or diminished returns