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Furthermore, the role of vitamin B12 in reducing homocysteine levels may also be relevant (30), as elevated homocysteine has been implicated in disruptions to hormone synthesis and metabolic homeostasis (31)
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However, given that this is the first pilot study to explore the clinical utility of serum GPX-3 concentration in patients with AAV, we believe that this study has clinical implications in that this identified a novel biomarker that can assess and estimate activity and damage caused by AAV at diagnosis, although confined to the time of diagnosis
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