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The takeaway points include: The use of MRI to observe changes in knee structures, especially fat tissue thickness, can provide a reasonably accurate diagnosis Inversion Recovery–Fast Spin-Echo (IR-FSE) Imaging when used in grading advanced disease, MR Arthrography and Intermediate Weighted-Fat Suppressed Fast Spin Echo Image (Iw-FS-FSE) are all techniques which offered both sensitivities and specificities greater than 80% The Patellar Sliding Test (PST) offered the highest sensitivity and specificity among clinical tests The VISA-P was the most specific (80.8%) out of the diagnostic questionnaires used to diagnose CP Table 4: Sensitivity and specificity of diagnostic tests in diagnosing chondromalacia patella Figure 12: Management strategies for chondromalacia patella Management Initial treatment should involve active therapies, that optimise joint loading, and biomechanics before interventions

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Mice were culled at the indicated ages