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using this technique disruption has also been reported in cSVD but caution needs to be used in interpretation because the reproducibility of functional networks has been shown to be very poor in cSVD (688, 689), possibly due to effect of the vascular pathology on neurovascular coupling on which the BOLD signal depends
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Transcriptional modifications may lead to disease progression, as transcriptomic analysis of bronchoalveolar lavage from severe COVID-19 patients showed reduced IFN-responsive genes response, compared to blood
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