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Consistent with this observation, SF significantly upregulated the expression of the rate-limiting enzyme glucose-6-phosphate dehydrogenase (G6PD) in the PPP in the HG environment only by 1.6 fold, and upregulated expression of transketolase (TKT) and transaldolase (TALDO), both involved in the non-oxidative branch of the PPP, 1.7-fold and 2.2-fold in HG cells (Table 2.)