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The effect of DMSO on the upregulation of DNMTs and subsequent hypermethylation of repeat sequences was in line with previous findings in mouse embryoid bodies 19
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[20] Patients should contact their GP or bariatric team promptly if they experience any of the following: New or worsening tingling, numbness, or weakness in the limbs Difficulty with balance, coordination, or memory Unexplained fatigue, breathlessness, or palpitations A sore or swollen tongue, or persistent mouth ulcers Any concern that they have missed supplementation for a prolonged period Symptoms that suggest anaemia, such as pallor or dizziness New or worsening neurological symptoms — such as paraesthesia, gait disturbance, or cognitive change — warrant same-day assessment