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Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements Precautions General Doses of vitamin B12 exceeding 10 mcg daily may produce a hematologic response in patients who have a folate deficiency
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Regrettably, for some patients, neoplastic recurrence or primary treatment resistant disease inhibits potentially curative approaches
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