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Starting at 4 h from the time of injury and for a duration of six months, a daily creatine dose of 0.4 g/kg of body weight was found to improve several TBI-related parameters and functional outcomes compared to placebo, such as the duration of post-traumatic amnesia, intubation and stay in intensive care units, the degree of disability and ultimate recovery from the insult, global cognition, as well as self-care, communication, locomotion, and sociability skills [53]
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