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Niacin, especially in high doses, can cause hyperuricemia
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At the same time, in the lipopolysaccharide-induced acute lung injury (ALI) model in rats, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) not only enhanced the activity of antioxidant enzymes (including superoxide dismutase [SOD], catalase [CAT], and glutathione [GSH]), effectively alleviated oxidative stress, but also inhibited the inflammatory response by downregulating the expression of the pro-inflammatory transcription factor NF-κB
