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This pathway is also involved in: sensoring the oxidative stress levels in oocyte and granulosa cells activating the steroidogenesis associated with luteinization (progesterone production) repressing the pro-inflammatory NF-KB pathway repressing the synthesis of COX enzyme involved in prostaglandins production (pro-inflammatory pathway) A recent mice study (47) showed that resveratrol promotes ovary and oocyte quality by interfering with a pesticide (mancozeb) used to induce accumulations of ROS (marker of oxidative stress)

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Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions