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For instance, the rs1050450 polymorphism in the GPX1 gene is linked to reduced enzyme activity and increased oxidative stress, exacerbating retinal damage in DR ( Furthermore, GWAS have identified new genetic loci and genes such as AKR1B1, GLUT1, COL18A1, MMP9, HIF1A, and CFH, which are linked to DR susceptibility, though further replication studies are needed to confirm these associations (Imamura et al., 2021