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Topical application has been the most commonly studied route in skin and wound research, while subcutaneous administration appears in systemic studies

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In conclusion, in a meta-analysis of four studies, which included 259 AD patients and 307 healthy controls, it was observed that AD patients had significantly lower serum vitamin E levels than the control group (standardized mean difference: -1.08, 95% CI: −1.80 to −0.36) (81)