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Although collagen is the primary ligand, GPVI also interacts with fibrin, laminin, fibronectin, vitronectin, galectin-3, adiponectin, and EMMPRIN, linking it to thrombus stabilization and vascular inflammation (Moroi et al., 2021)

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For Dihexa, those generic risks are compounded by a specific feature that makes them more consequential than they would be for most peripheral peptides