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By introducing neurotoxins such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), paraquat, and rotenone, toxin-based models suffer from overloaded oxidative stress which provokes the speedy degeneration of mDA that mimic the sporadic PD 17,18
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