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It is a 16-amino acid peptide that activates AMPK, the master metabolic regulator, by inhibiting the folate cycle and accumulating AICAR, a potent endogenous AMPK activator
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The ATTAIN-MAINTAIN Phase 3 trial specifically evaluated this scenario, testing whether patients who had achieved weight loss with injectable GLP-1 receptor agonists (semaglutide or tirzepatide) could switch to oral orforglipron while maintaining their weight loss
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