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Extensive preclinical studies identified the P2X7Rs as playing two roles in ALS: neuroprotective and neurodegenerative, depending on the disease stage, being predominantly neuroprotective in early disease stages while becoming gradually detrimental during ALS progression [248,249,250]

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OC is a complex disease that can be classified into five main subtypes: HGSOC, low-grade serous OC, serous, clear cell and mucinous (52)

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