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However, the finding that mutation of a single aminoacid residue can drastically alter the substrate specificity and other characteristics (Björnestedt et al., 1995b

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However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, diabetes, or a condition of fatigue)