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A daily oral supplement of 500-1000 mcg or a weekly dose of 2000 mcg can help maintain adequate levels, though evidence for routine prophylaxis specifically for tirzepatide users is limited

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Under normal physiologic conditions, the transport, storage, and utilization of iron is controlled by metabolic pathways involving proteins such as transferrin in plasma, transferrin receptors on the cell membrane for intracellular iron uptake through endocytosis, and the presence of intracellular ferritin, which can accommodate up to 4500 iron molecules and is used for iron storage [20,55,56]