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The convergence of AlphaFold-class structural prediction, generative AI design (à la Baker and Chai Discovery), and high-throughput automated synthesis platforms (generate-and-test pipelines now operating at 10,000+ compounds per week at facilities like Recursion Pharmaceuticals' robotic laboratory in Salt Lake City) means that the pipeline from identified inflammatory target to characterized peptide therapeutic will compress from decades to years

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MOTS-c: AMPK Activation (Signaling) MOTS-c works through cellular signaling — it activates a metabolic master switch: Secreted from mitochondria into the cytoplasm (and potentially into circulation as a "mitokine") Inhibits the folate-methionine cycle — specifically the de novo purine biosynthesis pathway Activates AMPK (AMP-activated protein kinase) — the cell's primary energy sensor AMPK translocates to the nucleus — directly regulating gene expression Result: Enhanced glucose uptake, improved insulin sensitivity, fatty acid oxidation, exercise-like metabolic effects This is a signaling cascade — MOTS-c triggers a metabolic program that mimics some effects of exercise