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accordingly, renal function is the principal determinant of systemic drug concentrations and, consequently, inner-ear drug accumulation ( Environmental factors, including NICU ambient noise levels, may potentiate ototoxicity through the activity-dependent MET channel uptake mechanism described in the Cellular Entry section above

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Tamaki J., Iki M., Kadowaki E., et al., “Biochemical Markers for Bone Turnover Predict Risk of Vertebral Fractures in Postmenopausal Women Over 10 Years: The Japanese Population‐based Osteoporosis (JPOS) Cohort Study,” Osteoporosis International 24, no

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