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Metformin was reported to alleviate oxidative stress in preeclampsia 46 and to inhibit high glucose-induced oxidative stress in type 2 diabetes-related osteoporosis 47 , both through activation of the Nrf2 signaling pathway
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PKC can phosphorylate DOR at S344 but is not required for DPDPE-induced DOR phosphorylation (Xiang et al., 2001)
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