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Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

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From a three-dimensional structural perspective, SIRT1 is composed of a highly conserved Rossmann-fold catalytic core domain and an additional structural domain comprising both a zinc-binding module and a helical module (Haigis and Sinclair 2010)

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