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These include reduced GHRH or ghrelin secretion, greater somatostatin inhibition, greater somatotroph sensitivity to IGF-I feedback, reduced pituitary responsiveness to GHRH, and reduced pituitary or hypothalamic responsiveness to ghrelin

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28, 30 Colchicine plasma concentrations can be doubled by concomitant CYP3A4 inhibitor use and quadrupled by concomitant P-glycoprotein inhibitor use