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NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD + and S-(5′-adenosyl)-L-methionine (SAM), and suppressed lipogenesis in adipocytes

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(PubMed) → Immune system tone (aging immunity context) Long-running clinical cohorts using Epithalamin reported improvements across cardiovascular, endocrine, immune, and nervous system indices, alongside lower all-cause and CV mortality—findings that need independent confirmation but line up with the broader biology of immunosenescence