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1 The 2014 Landmark Study A 2014 study set the foundation for NNMT investigations.8 It didn’t investigate 5-amino-1MQ directly, but it showed that NNMT links two important metabolic systems: NAD+ production through nicotinamide recycling and SAM-dependent methylation, establishing NNMT as a key regulator of metabolic pathways and supporting the development of selective inhibitors such as 5-amino-1MQ