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The ability of GH and IGF to modulate key signal transduction pathways such as the MAP kinase/ERK, Jak/STAT, and the PI3K/Akt pathway along with the subsequent effects on cell division and steroidogenesis indicates that these growth factors are centrally located to alter cell fate during proliferation and survival

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The impact of these changes is the capacity to induce a direct and reversible control of transcriptional regulation through these stress kinase pathways [22]