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In our opinion, even though all in vitro and in vivo studies provide useful information and hints for clinical trials with melatonin and DPP-4i or its combinational use, extensive work in clinical studies is still essential, and it may be possible to employ multi-functional drugs with a different mechanism of action to fight these multifactorial complications in DM of DNP and neuropathic pain

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IVs are available daily in our office