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Fluoroquinolone-Induced Tendinopathy—Epidemiology Although fluoroquinolones presented good tolerance in randomized clinical trials, further epidemiological studies have linked them to a higher risk of serious adverse effects (AEs), including neurotoxicity and collagen degradation [9], especially in generation IIa (e.g., ciprofloxacin, ofloxacin, levofloxacin) [27]

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