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161 , 1968–1971, doi: 10.1164/ajrccm.161.6.9907112 (2000)

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Current studies on metal nanozyme-hydrogel systems largely focus on in vitro cytocompatibility, hemolysis, and short-term oxidative stress as acute safety readouts for preliminary validation, whereas comparatively limited attention has been paid to the long-term degradation behavior of hydrogels, the in vivo metabolic fate of nanozymes, and the resulting systemic safety issues, including chronic immune responses, tissue fibrosis, or long-term organ accumulation