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The glutathione S -conjugate, cysteinylglycine S -conjugate, cysteine S -conjugate, and N -acetylcysteine S -conjugate (mercapturate) derived from halogenated alkenes are all nephrotoxic/hepatotoxic and in many cases nephrocarcinogenic/hepatocarcinogenic in experimental animals (e.g., Anders, 2004, Anders, 2008, Anders and Dekant, 1994, Anders et al., 1988, Boogard et al., 1989, Dekant, 2001, Dekant, 2003, Koob and Dekant, 1991, McGoldrick et al., 2003, Lash et al., 2014, Yaqoob et al., 2014, Cristofori et al., 2015)