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The diagnosis of MS is made according to clinical, radiological and, recently, biochemical criteria 3 and after diagnosis, early prediction of MS outcomes is a challenge because, until now, there is no strong candidate biomarker able to detect, early during disease course, those people with MS (pwMS) with subclinical neuronal damage and, therefore, more prone to develop clinical progression and functional impairment over time 4
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Furthermore, fundoplication is thought to anchor the cardia below the diaphragm, contributing to the reduction in the rate of recurrences [50]
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