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Interestingly, recent structural work has shown that phosphatidylinositol bisphosphate (PIP 2 ), a known interactor of PKC, binds to GABA A Rs, with the inositol head group positioned in close proximity to the desensitization gate 68 , perhaps providing a mechanism by which desensitization could promote the binding of PKC to the GABA A R and the phosphorylation of receptor subunits