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Keywords: Cystic fibrosis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, γ-glutamylcysteine ligase, infection and cigarette smoke The lung’s first line of defense, the airway fluid The lung epithelial lining fluid (ELF) is a continuous thin fluid containing a heterogeneous mixture of macromolecules that includes proteins, mucous, and surfactants as well as a number of low molecular weight antioxidants [1]