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Abbreviations ADAMs: a disintegrin and metalloproteinase AMPK: AMP-activated protein kinase CIN: chromosomal instability CRC: colorectal cancer DNA: deoxyribonucleic acid DNMT: DNA methyltransferases DR: death receptor EGCG: epigallocatechin gallate EGF: epidermal growth factor HDAC: histone deacetylase IC50 with lower case: half maximal inhibitory concentration KG: alpha ketoglutarate LCA: laccaic acid A LINE-1: long interspersed nuclear element lncRNA: long non coding RNA microRNAs: miRNAs MMPs: matrix metalloproteinases MSI: microsatellite instability RNA: ribonucleic acid SAM: S-adenosyl-L-methionine TET: ten-eleven translocation TNF: tumor necrosis factor TSG: tumor suppressor genes 5hmC: 5-hydroxymethylcytosine 5mC: 5-methylcytosine Declarations Acknowledgement The author acknowledges Mohamed Amine Jaafri for his help in revising the English

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PMID: 18568020 Biaggioni I (2024): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)