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In melanocytes, depending on the type of kinase and cell line, so far it has been proven that kinases play a dual role in Nrf2 activity regulation, e.g., increased activity of JNK (c-Jun N-terminal kinase) enhances Nrf2 expression in melanocytes line PIG1 but reducing its activation PIG3V cells 69
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For systemic or injectable use, interaction data is nonexistent, and the risk assessment defaults to the broader concerns already discussed: unverified purity, uncontrolled dosing, and absent human trials
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