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Importantly, a phenotype-oriented approach may improve clinical relevance, where MI may be prioritized in insulin-resistant individuals, vitamin D in deficient or inflammatory phenotypes, and melatonin in patients with pronounced oxidative stress or circadian disruption

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When used in combination with cisplatin or trastuzumab, for instance, Genexol ® has been demonstrated to increase the cytotoxicity of paclitaxel and improve overall treatment results in a variety of solid tumors [245]