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Phycochemistry and pharmacological significance of filamentous cyanobacterium Spirulina sp - PMC

Furthermore, we observed an increase of pro-apoptotic genes Bax, an increased level of reactive oxygen species, lower reduced glutathione level, and altered mitochondrial potential in response to CBD treatment leading to lower cellular ATP

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Because UAMC-3203 doesn’t cross the blood-brain barrier [31], we assume it is taken up at the time of blood-brain barrier disruption during the acute relapse phase