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To reach its full bioactivity, the prohormone undergoes amidation at the C-terminal and the formation of the disulfide between cysteine-2 and cysteine-7 [18]
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The covalent addition of these histone proteins including methylation, phosphorylation, sumoylation, acetylation, and ubiquitylation, have all been shown to be responsible for the epigenetic modifications (Paz et al., 2011)