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The disease is associated with a reduction in total HMBS enzyme activity by up to 50%, where the remaining activity derives from the presence of a normal allele expressing wild-type protein and any residual activity from the affected enzyme [11]
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236 Lifestyle factors, including nutritional therapy, especially the Mediterranean diet, 237 physical activity, 238,239,240 smoking cessation, 241 and quality sleep, are essential for preventing diabetes and its complications