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Another interaction region in the complex involves several oppositely charged residues: Lys36 hTrx1 –Glu103 hTrxR1 , Asp60 hTrx1 –Arg117 hTrxR1 , Asp64 hTrx1 –Lys146 hTrxR1 , Glu70 hTrx1 –Arg121 hTrxR1 , and Lys72 hTrx1 –Glu122 hTrxR1