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and when they use a separate syringe (such as Example 7 : AM833 ( cagrilintide (cagrilintide)) and semaglutide (semaglutide) 1 combined trial design 一項為期20週的多次遞增劑量第1期試驗係研究AM833(卡格林肽(cagrilintide))與2.4 mg司馬魯肽(semaglutide)組合投藥的安全性、耐受性、藥物動力學和減重潛力。在該試驗中，六種不同劑量的卡格林肽(cagrilintide) (每週0.16 mg、0.3 mg、0.6 mg、1.2 mg、2.4 mg和4.5 mg)與司馬魯肽(semaglutide)(每週2.4 mg)一起投藥，為六個獨立組的單獨皮下注射形式。個體以3：1的比例隨機接受卡格林肽(cagrilintide)+ 2.4毫克司馬魯肽(semaglutide)，或安慰劑+ 2.4 mg司馬魯肽(semaglutide)。進行為期16週的劑量遞增期，之後投予目標劑量4週。 80名初始BMI介於27.0至39.9 kg/m 2 (包括兩端)之間的成年人完成該試驗。A 20-week multiple escalating 2 (both ends inclusive) completed the test