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Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)

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While full-length EPO is primarily known for its role in red blood cell production, extensive experimental research has demonstrated that EPO-derived peptides can exert non-hematopoietic biological effects under controlled laboratory conditions